Table 5 Overlap of GWAS signals between nicotine dependence (cigarettes per day) and lung function traits.
From: Genetic Pleiotropy between Nicotine Dependence and Respiratory Outcomes
Lung Function Traits | GWAS P value threshold | Enrichment Fold | N of overlap SNPs | N of overlap SNPs of divergent risk direction | % SNPs of divergent risk direction | p-value of divergent risk direction |
|---|---|---|---|---|---|---|
FEV1 | 1.0E-06 | 261 | 26 | 26 | 100 | 6.32E-08 |
1.0E-05 | 127 | 26 | 26 | 100 | 6.32E-08 | |
1.0E-04 | 54.9 | 42 | 42 | 100 | 1.35E-12 | |
1.0E-03 | 4.61 | 71 | 65 | 91.55 | 4.34E-13 | |
1.0E-02 | 1.67 | 826 | 451 | 54.60 | 1.29E-2 | |
1.0E-01 | 1.03 | 29,067 | 15,404 | 52.99 | 9.00E-24 | |
FVC | 1.0E-06 | — | 0 | 0 | — | — |
1.0E-05 | — | 0 | 0 | — | — | |
1.0E-04 | 19.1 | 13 | 13 | 100 | 3.91E-04 | |
1.0E-03 | 3.50 | 49 | 47 | 95.92 | 1.17E-11 | |
1.0E-02 | 1.81 | 869 | 491 | 56.50 | 2.40E-04 | |
1.0E-01 | 1.07 | 29,865 | 15,840 | 53.04 | 4.47E-25 | |
FEV1/FVC Ratio | 1.0E-06 | — | 0 | 0 | — | — |
1.0E-05 | 63.90 | 14 | 14 | 100 | 2.08E-04 | |
1.0E-04 | 14.60 | 14 | 14 | 100 | 2.08E-04 | |
1.0E-03 | 2.28 | 39 | 39 | 100 | 9.80E-12 | |
1.0E-02 | 1.31 | 669 | 407 | 60.84 | 5.23E-08 | |
1.0E-01 | 1.03 | 28,468 | 14,474 | 50.84 | 6.70E-03 |
