Table 8 Co-localization of lung function and nicotine dependence GWAS signal at 15q25.1 locus*.
From: Genetic Pleiotropy between Nicotine Dependence and Respiratory Outcomes
Trait 1 | Trait 2 | N SNPs | PP.H0 | PP.H1 | PP.H2 | PP.H3 | PP.H4 |
|---|---|---|---|---|---|---|---|
FEV1 | Cigarettes Per Day | 1764 | 8.56E-32 | 1.46E-29 | 0.000537 | 0.091025 | 0.908438 |
Ever Smoked | 1762 | 0.005381 | 0.920954 | 0.000401 | 0.068663 | 0.004601 | |
Former Smoker | 1758 | 9.76E-05 | 0.016708 | 0.000502 | 0.084986 | 0.897706 | |
LogOnset | 1760 | 0.005601 | 0.95857 | 0.000172 | 0.029406 | 0.006252 | |
FVC | Cigarettes Per Day | 1764 | 2.52E-29 | 1.24E-29 | 0.157898 | 0.077069 | 0.765033 |
Ever Smoked | 1762 | 0.622132 | 0.306675 | 0.046387 | 0.022864 | 0.001942 | |
Former Smoker | 1758 | 0.048471 | 0.023889 | 0.249148 | 0.122238 | 0.556253 | |
LogOnset | 1760 | 0.648552 | 0.319665 | 0.0199 | 0.009806 | 0.002077 | |
FEV1/FVC Ratio | Cigarettes Per Day | 1764 | 1.17E-30 | 8.20E-30 | 0.007371 | 0.050554 | 0.942076 |
Ever Smoked | 1762 | 0.116032 | 0.810657 | 0.008652 | 0.060439 | 0.00422 | |
Former Smoker | 1758 | 0.002055 | 0.01436 | 0.010565 | 0.072912 | 0.900107 | |
LogOnset | 1760 | 0.120759 | 0.843642 | 0.003705 | 0.02588 | 0.006014 |
