Table 4 Association of Clinicopathological Features with PD-L1 Expression Based on the 22C3-IHC and SP142-IHC assays.

From: Assessment of Concordance between 22C3 and SP142 Immunohistochemistry Assays regarding PD-L1 Expression in Non-Small Cell Lung Cancer

Patient demographics (N=135)

22C3

SP142

Negative N (%)

P value

Positive N (%)

Negative N (%)

P value

Age (years)

>60 y

15 (11.1)

37 (27.4)

0.247

41 (30.4)

11 (8.1)

0.000

≤60 y

30 (22.2)

53 (39.3)

20 (14.8)

63 (46.7)

Sex

Male

36 (26.7)

62 (45.9)

0.221

52 (38.5)

46 (34.1)

0.003

Female

9 (6.7)

28 (20.7)

9 (6.7)

20 (20.7)

Smoking status

Never smoker

19 (14.7)

53 (41.1)

0.027

25 (19.4)

47 (36.4)

0.001

Smoker

26 (20.2)

31 (24)

36 (27.9)

21 (16.3)

Histology

SCC

24 (17.8)

29 (21.5)

0.053

35 (25.9)

18 (13.3)

0.001

AD

18 (13.3)

49 (36.3)

22 (16.3)

45 (33.3)

Other subtypes

3 (2.2)

12 (8.9)

4 (3.0)

11 (8.1)

TNM stage

I

22 (16.3)

40 (29.6)

0.557

36 (26.7)

26 (19.3)

0.418

II

11 (8.1)

16 (11.9)

12 (8.9)

15 (11.1)

III

11 (8.1)

30 (22.2)

22 (16.3)

19 (14.1)

IV

1 (0.7)

4 (3.0)

4 (3.0)

1 (0.7)