Table 3 Correlation of metabolites to each other and to standard measurements in CKD patients.

From: From Discovery to Translation: Characterization of C-Mannosyltryptophan and Pseudouridine as Markers of Kidney Function

Spearman correlation coefficient

Targeted LC/MS quantification

Plasma: Creatinine

Plasma: C-mannosyltryptophan

Plasma: Pseudouridine

Urine: Creatinine

Urine: C-mannosyltryptophan

Urine: Pseudouridine

Targeted LC/MS quantification

Plasma: Creatinine

1

     

Plasma: C-mannosyltryptophan

0.58

1

    

Plasma: Pseudouridine

0.71

0.88

1

   

Urine: Creatinine

0.01*

−0.06

−0.04

1*

  

Urine: C-mannosyltryptophan

−0.21

0.36

0.23

0.94*

1

 

Urine: Pseudouridine

−0.23

0.22

0.19

0.95*

0.69

1

Stand. clinical laboratory measurement

Serum: Creatinine

0.96

0.63

0.74

0.06*

−0.16

−0.23

Serum: Cystatin C

0.71

0.79

0.85

−0.02*

0.21

0.11

eGFR (based on serum creatinine)

−0.87

−0.70

−0.77

0.00*

−0.04

0.08

eGFR (based on cystatin C)

−0.66

−0.79

−0.84

0.02*

−0.28

−0.15

Urine: Creatinine

0.04

−0.04

−0.04

0.96*

0.89*

0.91*

Urine: UACR

0.06

0.00

0.04

−0.20*

−0.01

0.10

  1. Units for targeted measurements: plasma - µmol/L, urine - µmol/mmol creatinine or µmol/L (if not standardized for dilution, indicated by *); Units for standard clinical laboratory: serum creatinine: mg/dL, serum cystatin C: mg/L, eGFR: mL/min/1.73 m², UACR: mg/g. UACR: urine albumin-to-creatinine ratio.
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