Figure 1
From: Improving Gene Regulatory Network Inference by Incorporating Rates of Transcriptional Changes
ExRANGES Outperforms EXPRESSION in Identifying Targets for Select TFs. (A) ROC AUC for targets identified with GENIE3 using EXPRESSION or ExRANGES on five circadian TFs. The targets identified computationally were validated against ChIP-Seq identified targets28,29. (B) ROC AUC for targets computationally identified by GENIE3 analysis using EXPRESSION or ExRANGES for seven TFs not known to be components of the circadian clock. Experimentally validated targets for these TFs were identified by ChIP-Seq in epithelial cells, a tissue not included in the expression data set31.
