Table 3 Toxicity (IC50/MIC50) of NSC319726 to human liver cell lines Huh-7 and HepG-2 was measured at 24, 48, and 72 h post-treatment. The data are expressed as ratios of IC50/MIC50. Depending upon the time of incubation with the compound, the IC50 concentrations were 35–825-fold higher to achieve inhibition than the concentration to achieve an MIC50.
From: Repurposing an inhibitor of ribosomal biogenesis with broad anti-fungal activity
hours | Huh-7 Cells | HepG-2 Cells |
|---|---|---|
24 h | 825 | 780 |
48 h | 330 | 330 |
72 h | 35 | 35 |
