Figure 1

Schematic for nanocapsid and AuNC cysteine conjugation. (a) X-Ray cystral structure of nanocapsid dimer highlighting 573 C binding site on the nancapsid P-domain. (b) When dimer building blocks associate to form a pentamer, 573 C sites faces the 5-fold center. The crystal structure of this pentamer was docked over a surface rendition of the full T = 1 nanocapsid crystal structure³⁶. (c) The cysteine-reactive sites on AuNC constructs²³ are depicted with a black arrow, illustrating cysteine replacement site for Au₁₀₂ (top) and the maleimide-thiol coupling site in Au₁₀₂_C₆MI (bottom).