Figure 3
(A) OPLS-DA score plot was comprised 7 putative biomarkers (Table 4) quantified in 117 patients. Green observations (64 samples) represent patients receiving a GC dose of 1–5 prednisolone equivalent and the blue observations (53 samples) represent patients receiving GC dose >5–15 mg prednisolone equivalent. The model consists of one predictive x-score components; component t[1] and one orthogonal x-score component to[1]. t[1] explains 33.7% of the predictive variation in x, to[1] explains 23% of the orthogonal variation in x, R2X (cum) = 0.57, R2Y (cum) = 1, R2 (cum) = 0.535, Goodness of prediction Q2 (cum) = 0.497. Plot (B) showing area under the ROC curve (AUC) of the two groups, x-axis showing (FPR) false positive rate (1-specificity), y-axis showing true positive rate (sensitivity). AUC for 1) 1–5 = 0.92 and 2) >5–15 = 0.92.
