Figure 4 | Scientific Reports

Figure 4

From: High expression of β-catenin contributes to the crizotinib resistant phenotype in the stem-like cell population in neuroblastoma

Figure 4

β-catenin siRNA knockdown restores the binding between crizotinib and ALK and significantly sensitizes RR cells to crizotinib treatment. (A,B) β-catenin siRNA knockdown significantly restores crizotinib—ALK binding upon crizotinib treatment in comparison to scrambled siRNA transfection in RR cells derived from GOTO and SK-N-SH. Representative western blots are shown on the upper panel and the densitometry quantification data from 3 independent experiments are shown on the lower panel. (C,D) RR cells significantly sensitized to crizotinib treatment upon β-catenin siRNA knockdown. Data are presented as mean ± SD. **P < 0.01, Student’s t test.

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