Figure 6

Time-versus-Subject Contribution to Variance Analysis. (a) Percent contribution to variance by subject versus time-of-day is displayed for the multiomic, e.g. for cortisol, as expected, the time variance contribution is higher than by subject. Note that time-of-day refers to the three morning and two evening replicates within one 48 hour session. We defined a 5% cutoff (dotted line) to discern variables with a higher time-of-day from subject contribution to variance. (b) Readouts collected from remote sensors and wearable devices segregate according to the percent degree of how much variance is contributed by subject versus time, e.g. for blood pressure (SBP, DBP) the variance contribution by time is higher than by subject, thus underscoring the diurnality of this phenotype. (SBP/DBP: systolic/diastolic blood pressure; MAP: mean arterial pressure; HR: heart rate; PP: pulse pressure). (Insert) This blow up magnifies for dietary food the percent contribution to variance by subject versus time-of-day. Time-specific data was collected by the phone application SmartIntake© during the 48 hrs sessions. (Axis 1–3 refer to the Actigraph’s accelerometers).