Figure 2 | Scientific Reports

Figure 2

From: Adeno-associated virus serotype rh10 is a useful gene transfer vector for sensory nerves that innervate bone in immunodeficient mice

Figure 2The alternative text for this image may have been generated using AI.

Distribution of AAV vectors in DRG. GFP-tagged AAV vectors (AAV2, 5, 6, 8, 9, and rh10) were placed intrathecally between the L4/5 vertebrae of immunodeficient mice by percutaneous lumbar puncture. At 4 weeks, DRGs were collected for immunofluorescence analyses for GFP positivity to determine AAV distribution. (A) Representative image of L3 DRGs obtained from AAV injected mice. Magnification, × 20. Scale Bar = 100 µm. (B) Quantifications of (A). (C,D) Quantifications of GFP positivity of (C) L2 and (D) L4 DRGs obtained from AAV injected mice. Presented as mean ± standard deviation, Significant differences were determined by one-way ANOVA with Tukey’s multiple comparisons. *p ≤ 0.05, ***p ≤ 0.0001, ****p ≤ 0.00001.

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