Figure 7
From: Peroxiredoxin activity is a major landmark of male fertility
Signalling pathways associated with PRDXs and hypothetical illustration of PRDXs in mouse spermatozoa. (A) Protein-protein interactions, cellular regulations, and associated diseases related to PRDX activity illustrated using the Pathway Studio program. (B) Hypothetical illustration demonstrates the effect of conoidin A on sperm function and fertilisation. Conoidin A decreases PRDX activity in spermatozoa, which is associated with the alteration of several sperm functions, including motility, viability, and capacitation status, perhaps as a consequence of altered reactive oxygen species (ROS), DNA fragmentation index (DFI), mitochondrial membrane potential (MMP), ATP levels, PKA activity, and tyrosine phosphorylation. All of these changes ultimately affect fertilisation and early embryonic development.
