Figure 3 | Scientific Reports

Figure 3

From: cfDNA correlates with endothelial damage after cardiac surgery with prolonged cardiopulmonary bypass and amplifies NETosis in an intracellular TLR9-independent manner

Figure 3

Plasma levels of inflammatory biomarkers and leukocyte counts in patients undergoing cardiac surgery with CPB. Levels of soluble thrombomodulin (sCD141, (a) short-CPB (Admission n = 20; Post-op n = 18; d1 n = 20; d3 n = 19; d5 n = 17; d8 n = 13); long-CPB (Admission n = 22; Post-op n = 14; d1 n = 20; d3 n = 19; d5 n = 21; d8 n = 15)), ICAM-1 (b) short-CPB (Admission n = 15; Post-op n = 12; d1 n = 13; d3 n = 15; d5 n = 14; d8 n = 11); long-CPB (Admission n = 14; Post-op n = 11; d1 n = 13; d3 n = 16; d5 n = 16; d8 n = 15)) and IL-6 (c) short-CPB (Admission n = 19; Post-op n = 18; d1 n = 20; d3 n = 21; d5 n = 20; d8 n = 14); long-CPB (Admission n = 20; Post-op n = 16; d1 n = 21; d3 n = 21; d5 n = 22; d8 n = 20)) were quantified in patients’ plasma by commercially available Elisas at the times indicated. CRP levels (d) short-CPB (Admission n = 22; d1 n = 22; d3 n = 20; d5 n = 20; d8 n = 16); long-CPB (Admission n = 26; d1 n = 26; d3 n = 26; d5 n = 26; d8 n = 25)) and leukocyte counts (e) short-CPB (Admission n = 22; d1 n = 22; d3 n = 22; d5 n = 21; d8 n = 18); long-CPB (Admission n = 26; d1 n = 26; d3 n = 26; d5 n = 26; d8 n = 25)) were measured routinely in all patients. *p < 0.05; &p < 0.01, $p < 0.001 vs. admission.

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