Table 2 Comparison of G6PD activity and G6PD/6PGD ratio among six prevalent gene mutations.

From: Newborn screening of glucose-6-phosphate dehydrogenase deficiency in Guangxi, China: determination of optimal cutoff value to identify heterozygous female neonates

Genotype

Classification

G6PD activity

P value*

G6PD/6PGD ratio

P value

c.1376 G > T

II

0.563 ± 0.265

<0.0001

    

0.197 ± 0.083

<0.0001

    

c.95 A > G

II

0.832 ± 0.312

<0.0001

   

0.220 ± 0.084

<0.0001

   

c.1388 G > A

II

0.969 ± 0.340

 

0.0020

  

0.259 ± 0.098

 

0.2140

  

c.871 G > A

II

1.089 ± 0.402

  

<0.0001

 

0.259 ± 0.091

  

<0.0001

 

c.1024 C > T

III

1.465 ± 0.334

   

0.3583

0.454 ± 0.108

   

0.1800

c.392 G > T

III

1.526 ± 0.296

    

0.517 ± 0.136

    
  1. *The value in each box represents the significance of difference between the two neighbouring G6PD mutations. P value less than 0.0001 indicates that there is significant difference of enzyme activity or G6PD/6PGD ratio among these six G6PD mutations.
Back to article page