Figure 2

Scheme showing metabolism of acrylamide (AA) and formation of corresponding adducts. AA and glycidamide (GA) can form adducts to hemoglobin at N-terminal valine; represented as AA-(Val)-Hb and GA-(Val)-Hb, respectively. GA can react with cob(I)alamin [Cbl(I)], unlike AA, to form the cobalamin adduct GA-Cbl.