Table 2 AUC of AA and of GA in human and rat calculated from measured Hb adducts.

From: Parallelogram based approach for in vivo dose estimation of genotoxic metabolites in humans with relevance to reduction of animal experiments

AUCs (in nM·h/μg AA per kg bw)

Human

Rat

AUC-AA

212 ± 56

34 ± 3

AUC-GA

49 ± 17

18 ± 1

AUC-GA per AUC-AA

0.23 ± 0.05

0.53 ± 0.07

  1. Note: Values given as mean ± standard deviation.
  2. Human data from intake of ca. 11 μg AA/kg bw and day (n = 9), repeated daily dosing during 4 days through food23. Rat data from exposure to two different doses, 500 and 2000 μg AA/kg bw and day (n = 3 at each dose), repeated daily dosing during one week through drinking water24.
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