Figure 4 | Scientific Reports

Figure 4

From: Involvement of TRPM2 and TRPV1 channels on hyperalgesia, apoptosis and oxidative stress in rat fibromyalgia model: Protective role of selenium

Figure 4

Effects of selenium (Se) on TRPV1 channel activation in dorsal root ganglion neuron (DRGN) of control and FM-induced rat. The TRPV1 currents in DRGN were stimulated by extracellular CAPS (10 μM in patch chamber) but they were blocked by extracellular CPZ (0.1 mM) in the patch-chamber. W.C. is whole cell. (a) Control: Original recordings from control neuron. (b) Control + CAPS group (without FM induction). (c) FM group (with FM induction). (d) FM + Se group: Se was administrated to the rats after FM induction. (e) Se group: Se was administrated to the rats without FM induction. (f) TRPV1 channel current densities in the DRGN. The numbers in parentheses indicated n numbers of groups. (a p ≤ 0.001 versus control. b p ≤ 0.001 versus control + CAPS group. c p ≤ 0.001 versus control + CAPS + CPZ group. d p ≤ 0.001 versus FM + CAPS group. e p ≤ 0.001 versus FM + CAPS + CPZ group).

Back to article page