Figure 2 | Scientific Reports

Figure 2

From: Selective targeting of Scn8a prevents seizure development in a mouse model of mesial temporal lobe epilepsy

Figure 2

Schematic of experimental design. (a) Schedule of treatment, EEG, behavioral, and histological analyses. Mice were administered KA, followed by AAV constructs 24 hours later (post-status epilepticus). Continuous video/EEG analyses were performed for 8 weeks, followed by 2 weeks of behavioral analyses, and histological analyses at week 10 post-KA. (b) Depth EEG recording electrodes were placed in the dorsal hippocampus (coordinates relative to bregma and from the surface of the brain: (AP) −1.8 mm, (ML) ± 1.6 mm, (DV) −1.7 mm). A guide cannula (for KA and AAV administration) was attached laterally to the depth electrode in the right dorsal hippocampus. Brain image adapted from Allen Brain Atlas. (c) Representative image of hippocampus and GFP expression.

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