Figure 4

Scn8a knockdown reduces KA-induced hyperactivity. (a,b) Distance travelled and average speed were significantly higher in KA-only mice and mice treated with shRNA-scram when compared to shRNA-Scn8a-treated and surgery-only mice. (N = 6–11/group). (c) Time spent in center (open field paradigm) and (d) time spent in the dark (light/dark box paradigm) were comparable between all groups of mice. (N = 6–11/group). One-way ANOVA followed by the Holm-Sidák’s multiple comparisons test. (e) Percent of time spent exploring the novel object was not significantly different between all groups but was significantly greater than 50% chance. (N = 4–7/group). One-tailed student’s t test. All data are presented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001.