Figure 2

Microbial clades and pathways associated with oral cancer and with clinical, environmental, and demographic covariates. (a) Clades (tree includes all microbes in the dataset) and (b) pathways (shown on the KEGG BRITE hierarchy) differentially abundant with respect to oral cancer (highlighted points) and a subset of non-cancer covariates in this cohort (outer bands), comprising periodontal health, tumor HPV status, tobacco usage, and tooth status; multivariate model is as in Fig. 1 and Methods. Highlighted associations are significant at FDR q < 0.25, n as in Table 1.