Figure 8

CB2Rs in DA neurons modifies alcohol preference. (a–f). The 5-day sub-acute stress modifies alcohol preference ratio (a,d) with the DAT-Cnr2 cKO consuming less alcohol (P < 0.05) than the wild type mice, with or without acute stressor. In the chronic mild stress model (b,c), there was significant reduction (P < 0.05) in the consumption of 2% sucrose by the wild type mice in comparison to the DAT-Cnr2 cKO mice. At the end of the seven week CMS period, there was increased alcohol consumption (e) by the wild type mice in comparison to non-stressed wild type and stressed and non-stressed DAT-Cnr2 cKO mice. There were significant weight changes (f) (P < 0.01) following CMS in both the wild type and DAT-Cnr2 cKO mice compared to non-stressed wild type and DAT-Cnr2 cKO mice. Data for the CMS studies are presented as mean ± SEM with 6 mice per group and *P < 0.05, **P < 0.01 for DAT-Cnr2 cKO and wild type mice.