Table 2 Factors associated with the rate of retinal nerve fiber layer thinning (n = 87).

From: Lamina Cribrosa Morphology Predicts Progressive Retinal Nerve Fiber Layer Loss In Eyes with Suspected Glaucoma

Variables		Global				Superior sector				Inferior sector
		Univariate		Multivariate		Univariate		Multivariate		Univariate		Multivariate
		ß	P	ß	P	ß	P	ß	P	ß	P	ß	P
Age, per 1-year older		−0.012	0.038	−0.016	0.001	−0.012	0.263			−0.029	0.023	−0.028	0.008
Gender, female		0.141	0.26			0.586	0.016	0.518	0.042	−0.163	0.574
Diabetes mellitus		−0.26	0.096	−0.07	0.445	−0.195	0.529			−0.882	0.013	−0.104	0.902
Hypertension		0.064	0.637			−0.036	0.892			0.236	0.447
Family history of glaucoma		0.32	0.151			0.397	0.369			0.916	0.074	0.02	0.88
Cold extremities		0.017	0.913			0.036	0.903			0.384	0.268
Migraine		0.181	0.452			0.151	0.751			0.837	0.129
Baseline IOP, mmHg		−0.039	0.045	−0.32	0.052	−0.052	0.173			−0.073	0.1
Mean IOP during follow-up, mmHg		−0.031	0.202			−0.05	0.301			−0.047	0.397
IOP fluctuation during follow-up, mmHg		−0.140	0.140			−0.06	0.752			−0.285	0.195
Refractive error (spherical equivalent), diopters		0.024	0.482			0.102	0.122			0.005	0.95
Central corneal thickness, μm		−0.001	0.777			−0.006	0.08	−0.13	0.228	0.001	0.835
Axial length, mm		−0.02	0.749			−0.088	0.501			0.092	0.53
Visual field MD, dB		−0.023	0.691			−0.026	0.805			0.033	0.795
Visual field PSD, 1dB		0.168	0.403			0.191	0.640			0.279	0.526
Cup to disc ratio	Horizontal	−1.486	0.074	0.120	0.367	−3.059	0.062	−0.141	0.187	−0.345	0.071	−0.111	0.449
Cup to disc ratio	Vertical	−2.651	0.002	−1.890	0.013	−4.174	0.015	−0.144	0.186	−4.385	0.029	−3.274	0.040
Baseline RNFL thickness, μm*		0.006	0.354			−0.002	0.742			−0.007	0.421
Number of SD-OCT scan		−0.010	0.761			0.083	0.180			−0.122	0.087	−0.084	0.952
LCD^†	Average of 7 planes	−0.002	0.004	−0.033	0.797
	Average of superior- most 2 planes					−0.002	0.081	0.068	0.597
	Average of inferior- most 2 planes									−0.004	0.003	−0.025	0.530
LCCI^†	Average of 7 planes	−0.167	<0.001	−0.14	<0.001
	Average of superior- most 2 planes					−0.218	0.001	−0.192	0.005
	Average of inferior- most 2 planes									−0.354	<0.001	−0.328	< 0.001

IOP = intraocular pressure; MD = mean deviation; PSD = pattern standard deviation; RNFL = retinal nerve fiber layer; LCD = lamina cribrosa depth; LCCI = lamina cribrosa curve index. *Baseline RNFL thickness means circumpapillary RNFL thickness at corresponding area. ^†The average values were defined as the mean values of the measurements from the 7 planes (from superior to inferior peripheral plane). Only variables with P < 0.1 on univariate analysis were included in the multivariate model. Values with statistical significance are in boldface.

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Table 2 Factors associated with the rate of retinal nerve fiber layer thinning (n = 87).

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