Figure 8
(a–e) Markers associated with TGF pathway induced renal fibrosis. mRNA expression of Pai1, Tgfβ, αSMA, Mmp2 and Timp2 in renal cortical tissues of WT and DCM mice administered NAC or saline (n = 5–8). Data are mean ± SEM. *P < 0.05 vs saline treated WT mice. P values were derived from a one-way ANOVA followed by Tukey post-hoc test. Pai1 = plasminogen activator inhibitor-1, Tgfβ = transforming growth factor beta, αSMA = alpha smooth muscle actin, Mmp2 = matrix metalloproteinase-2, Timp2 = tissue inhibitor of metalloproteinase 2. Other abbreviations are as for Fig. 1.
