Table 1 Interruption time, difference from baseline to minimum value (Δ min) of SpO₂ and O₂ pocket and difference from baseline to maximum value (Δ max) of etCO₂ and CO₂ pocket per subject and test.

Subject	Test series 1							Test series 2							Test series 3
Subject	Interruption time (min: s)			Δ min SpO₂* (%)	Δ max etCO₂* (mmHg)	Δ min O₂ pocket (%)	Δ max CO₂ pocket (%)	Interruption time (min: s)			Δ min SpO₂* (%)	Δ max etCO₂* (mmHg)	Δ min O₂ pocket (%)	Δ max CO₂ pocket (%)	Interruption time (min: s)			Δ min SpO₂* (%)	Δ max etCO₂* (mmHg)	Δ min O₂ pocket (%)	Δ max CO₂ pocket (%)
1	30	0		−4	na	−8.20	4.99	11	0	(a)	−22	14	−11.49	5.90	13	0	(a)	−25	21	−11.56	5.92
2	30	0		−6	na	−7.39	4.57	30	0		−4	7	−7.68	4.65	8	6	(b)	−12	35	−11.16	6.03
3	9	30	(a)	−25	13	−10.06	5.36	10	36	(a)	−28	14	−11.29	5.63	10	5	(a)	−24	16	−12.19	5.90
4	5	55	(a)	−21	5	−7.93	4.11	7	0	(a)	−25	7	−9.31	4.95	5	55	(a)	−24	16	−9.50	4.40
5	30	0		−15	18	−9.70	5.05	8	30	(a)	−27	18	−10.39	4.69	7	3	(a)	−25	14	−12.66	5.46
6	30	0		−2	12	−7.49	4.77	30	0		−3	12	−7.70	4.93	12	15	(b)	−22	22	na	na
7	30	0		−12	7	−10.26	5.48	23	11	(b)	−21	37	−11.39	6.14	8	20	(a)	−27	19	−10.09	5.76
8	30	0		−12	18	−9.99	5.79	30	0		−21	11	−11.38	6.12	11	18	(a)	−25	20	−12.33	5.75
9	30	0		−9	9	−8.60	4.56	30	0		−6	11	−7.61	4.81	30	0		−13	11	−11.09	5.00
10	30	0		−9	22	−9.30	4.93	24	20	(b)	−19	34	−10.99	6.08	11	12	(a)	−23	25	−11.76	5.74
11	30	0		−5	4	−5.69	3.85	17	11	(b)	−20	23	−7.99	4.87	30	0		−9	12	−9.51	5.32
12	30	0		−7	19	−8.06	4.22	30	0		−16	42	−10.59	5.82	30	0		−9	21	−10.09	5.52
Ctrl 1	3	30		−22	54	nn	nn	3	20		−27	21	nn	nn	3	48		−29	29	nn	nn
Ctrl 2	3	12		−24	15	nn	nn	3	8		−40	16	nn	nn	2	50		−24	44	nn	nn

(a) indicates interruption due to SpO₂ ≤ 75% and (b) interruption requested. *For control subjects difference from baseline to stop value. Ctrl, control; etCO₂, end tidal CO₂; SpO₂, peripheral oxygen saturation. na, value not available due to technical failure. nn, value not measured due to the experimental protocol.

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