Table 3 Stratified analysis by gender for hazard ratios of cardiovascular diseases and all-cause mortality.

From: Estimated Glomerular Filtration Rate, Proteinuria, and Risk of Cardiovascular Diseases and All-cause Mortality in Diabetic Population: a Community-based Cohort Study

 

eGFR (ml/min/1.73 m2)a

Proteinuriab

≥90

60–89

45–60

<45

P for trend

No

Yes

Men

CVDs

 Age-adjusted

Ref.

1.16(0.95–1.42)

1.20(0.90–1.59)

1.18(0.78–1.79)

0.25

Ref.

1.36(1.11–1.68)

 Multivariable

Ref.

1.12(0.90–1.39)

1.04(0.76–1.43)

1.03(0.64–1.65)

0.85

Ref.

1.18(0.94–1.48)

All-cause mortality

 Age-adjusted

Ref.

1.05(0.86–1.29)

1.31(1.00–1.70)

1.41(0.98–2.02)

0.01

Ref.

2.20(1.86–2.61)

 Multivariable

Ref.

0.96(0.77–1.19)

1.21(0.91–1.61)

1.47(1.00–2.18)

0.03

Ref.

2.15(1.79–2.59)

Women

CVDs

 Age-adjusted

Ref.

0.79(0.46–1.33)

1.13(0.57–2.25)

1.60(0.66–3.86)

0.29

Ref.

2.02(1.23–3.34)

 Multivariable

Ref.

0.83(0.45–1.53)

1.41(0.61–3.25)

1.43(0.44–4.66)

0.36

Ref.

1.92(1.09–3.40)

All-cause mortality

 Age-adjusted

Ref.

1.72(0.85–3.47)

2.37(1.05–5.34)

3.04(1.17–7.91)

0.02

Ref.

3.48(2.23–5.45)

 Multivariable

Ref.

2.20(0.99–4.88)

3.49(1.36–8.96)

4.26(1.38–13.19)_)

0.01

Ref.

3.96(2.39–6.57)

  1. Abbreviation: eGFR = estimated Glomerular Filtration Rate; CVD = Cardiovascular Diseases.
  2. aP interaction of gender and eGFR for CVDs is 0.26; P interaction of gender and eGFR for all-cause mortality is 0.64.
  3. bP interaction of gender and proteinuria for CVDs is 0.08; P interaction of gender and proteinuria for all-cause mortality is 0.03.
  4. cAdjusted for age, gender, education, income level, smoking status, drinking status, physical activity frequency, salt intake, family history of myocardial infarction, family history of stroke, hypertension, dyslipidemia, atrial fibrillation, use of antihypertensive drugs, use of lowering lipid drugs, use of antidiabetes drugs, resting heart rate, fasting plasma glucose, body mass index, systolic blood pressure, diastolic blood pressure, triglycerides, total cholesterol, low density lipoprotein cholesterol, high density lipoprotein cholesterol, uric acid, C-reactive protein, and serum creatinine.
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