Figure 3
From: BKIP-1, an auxiliary subunit critical to SLO-1 function, inhibits SLO-2 potassium channel in vivo
BKIP-1 does not alter SLO-2 Ca2+ sensitivity. (a) Effects of Ca2+ concentration on SLO-2 channel activity. Shown are representative current traces of inside-out patches (holding voltage +30 mV) from body-wall muscle cells of SLO-2 (n = 16) and SLO-2+ BKIP-1 (n = 16), which represent shk-1(ok1581);bkip-1(zw10) and shk-1(ok1581) strains, respectively. Cl− concentration in the bath solution was kept constant (50 mM). (b) Ca2+ concentration and SLO-2 open probability (nP o ) curves fitted to the Hill’s equation, and comparison of the slope and the half maximal effective concentration (EC 50 ) between the two groups. All values are shown as mean ± SE.
