Figure 5
From: BKIP-1, an auxiliary subunit critical to SLO-1 function, inhibits SLO-2 potassium channel in vivo
BKIP-1 regulates body-wall muscle action potential properties. (a) Sample current-clamp traces from SLO-2 and SLO-2 + BKIP-1, which represent shk-1(ok1581);bkip-1(zw10) and shk-1(ok1581) strains, respectively, and comparison of the resting membrane potential (RP), the mean amplitude of action potentials (spikes), number of spikes per train, and inter-spike interval. (b) Representative action potentials from SLO-2 and SLO-2 + BKIP-1 superimposed, comparison of the 10–90% rise time, 10–90% decay time and mid-peak width of action potentials, and comparison of the amplitude of afterhyperpolarization. Each dot in a graph represents the mean value of all the events of one recording. All values are shown as mean ± SE. The double asterisk (**) indicates a statistically significant difference (p < 0.01) whereas “ns” indicates no statistically significant difference (p > 0.05) compared between SLO-2 (n = 13) and SLO-2 + BKIP-1 (n = 13) (unpaired t-test).
