Figure 7
From: Knockdown of long non-coding RNA H19 inhibits multiple myeloma cell growth via NF-κB pathway
A schematic representation of the proposed model: possible mechanism of H19 via the NF-κB pathway regulated growth of MM. H19 induced phosphorylation of the typical IκBα, marking it for degradation, thus led to an enhanced nuclear NF-κB accumulation. Otherwise, H19 could directly promote P65 phosphorylation. Subsequently, nuclear P65 might bind to IL-6 and IL-8 promoter regions, and promoted their transcription.
