Table 1 Motility, cell stiffness and pAXL level in six lung cancer cell lines.

From: Cell softening in malignant progression of human lung cancer cells by activation of receptor tyrosine kinase AXL

 

Motility

Average value of Young’s moduli

pAXL level

Transwell assay (No. of migrated cells)

Wound-healing assay (μm/24 h)

(E: kPa)

(×10−1, normalized with total AXL

Adenocarcinoma

A549

83.5 ± 24.3**

10.8 ± 3.1**

2.71 ± 0.14**

0.05 ± 0.02*

H322

10.5 ± 4.4**

9.5 ± 5.3**

3.01 ± 0.31**

0*

Squamous cell carcinoma

H1703

85.3 ± 25.3**

13.0 ± 2.8**

3.18 ± 0.38**

0*

LC-AI

312.8 ± 111.6

43.2 ± 8.8

1.44 ± 0.06

0.34 ± 0.12

Large cell carcinoma

H1299

229.6 ± 70.9

33.0 ± 2.1

1.75 ± 0.04

1.23 ± 0.67

Lu99

257.9 ± 71.2

37.8 ± 8.4

1.66 ± 0.08

0.31 ± 0.14

  1. A549, H322, and H1703 cells belong to LMHS group, and LC-AI, H1299, and Lu99 cells belong to HMLS group. “*” indictes statistical differences between LMHS and HMLS groups. *p < 0.05, **p < 0.01.
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