Table 2 Cellular effects of activation or inhibition of AXL activity in lung cancer cell lines.

From: Cell softening in malignant progression of human lung cancer cells by activation of receptor tyrosine kinase AXL

Induced

High AXL in cells of LMHS group

Low AXL in cells of HMLS group

by transfection of AXL gene by AXL ligand, Gas 6

by AXL-targeting siRNA by AXL inhibitor, R428 by Ras/Rac inhibitor, SCH 51344*

pAXL

increased

decreased

Motility

increased

decreased

Tumour formation

n.d.

decreased

Cell stiffness

decreased

increased

Actin stress fibre

decreased

increased

  1. HMLS: high motility-less stiffness; LMHS, low motility-high stiffness.
  2. n.d.: not determined.
  3. *Induced similar phenotypes to low AXL.
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