Figure 3
From: TRPV1 enhances the afferent response to P2X receptor activation in the mouse urinary bladder
TRPV1 is coupled to P2X mediated afferent firing. (a) Peak afferent nerve responses to bath applied DMPP (100 µM) in TRPV1+/+ and TRPV1−/− mice. (b) Bladder contraction responses to αβMe-ATP (30 µM) in the presence (white bars) and absence (black bars) of capsazepine in TRPV1+/+ and TRPV1−/− mice. (c) pressure/volume relationship within the bladder when distended with saline in TRPV1+/+ and TRPV1−/− mice. (d) Afferent nerve response to repeated applications of αβMe-ATP for 60 s in calcium free modified krebs solution with, or without, capsazepine (10 µM); Data shown are mean ± SEM, two-way ANOVA with Bonferroni post-test ****p ≤ 0.0001 (n = 7). (e) Afferent response to αβMe-ATP (30 µM) in calcium free modified Krebs solution with or without capsazepine. Data shown are mean ± SEM, one-way ANOVA with Tukeys post-hoc test ns p ≥ 0.05, *p < 0.05 (n = 7).
