Figure 5
From: TRPV1 enhances the afferent response to P2X receptor activation in the mouse urinary bladder
The effect of TRPV1 on urothelial responses to P2X stimulation. (a) Relative expression of TRPV1 in PMUC and pelvic DRG neurons;; Data are mean ± SEM, two tailed un-paired t-test ***p ≤ 0.001 (n = 3); (b) normalised concentration response curve of PMUC intracellular calcium to ATP in TRPV1+/+ and TRPV1−/− mice (n = 6); (c) change in intracellular calcium levels of PMUCs to capsaicin and ATP; (d) intraluminal ATP and (e) acetylcholine release from TRPV1+/+ and TRPV1−/− mouse bladders; Data are mean ± SEM, one-way ANOVA with Tukeys post-hoc test **p ≤ 0.01, ***p ≤ 0.001 (n = 6).
