Figure 2 | Scientific Reports

Figure 2

From: Deep sequencing of blood and gut T-cell receptor β-chains reveals gluten-induced immune signatures in celiac disease

Figure 2

TRBV gene usage is substantially perturbed upon gluten exposure in CD patients. TRBV gene usage in treated versus untreated repertoires is shown for selected gene segments. Heat maps show differentially used TRBV genes in at least one patient (fisher’s exact test, BH adjusted p-values < 0.05), numbers are p-values, green shows odds ratio (OR) > 1 (over-representation) and red OR < 1 (under-representation) during gluten exposure. (a) and (b) show the result for patient PBMC and gut repertoires respectively when TRBV gene usage is compared at unique clonotypes. (c) and (d) for patient PBMC and gut repertoires respectively when TRBV gene usage is compared using all reads.

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