Figure 3
Inter-individual repertoire overlap comparison. (a) Increased inter-individual amino acid repertoire overlap is observed in gut biopsy samples during gluten exposure (n = 10 possible pairs at each time point for the 5 CD GUT samples, Wilcoxon paired Signed Rank test, **p = 0.01), while CD patient PBMC repertoires show non-significant increase in overlap. (b) No increased inter-individual overlap is observed in the nucleotide repertoires of both PBMC and gut biopsy samples during gluten exposure. (c) Inter-individual repertoire overlap for combined data (4 CD PBMC and 5 CD GUT samples, n = 36).The evidence for public component in the response to gluten is stronger when repertoire types are combined for the overlap analysis, showing even higher inter-individual repertoire overlap between unrelated individuals and repertoires drawn from separate tissues (Wilcoxon paired Signed Rank test, **P = 0.0002). PBMC-gut pairs show significantly increased overlap during gluten exposure (Wilcoxon paired Signed Rank test, **P = 0.0064). Horizontal bars indicate median. Patient PBMC pairs are in triangles, gut biopsy pairs are in circles, mixed pbmc-gut pairs are in rectangles.
