Table 2 Relative Predispositional Effect (RPE) analysis locus summary.

From: Genome-wide association study of self-reported food reactions in Japanese identifies shrimp and peach specific loci in the HLA-DR/DQ gene region

Locus

RPE step

Peach allergy

Shrimp allergy

Significant alleles excluded

P-value

Significant alleles excluded

P-value

HLA-DRB1

0

none

4.27E-11

none

8.48E-15

1

09:01

9.25E-08

04:05

1.58E-02

2

09:01, 14:05

2.16E-05

04:05, 15:01

1.35E-01

3

09:01, 14:05, 15:01

0.0028

  

4

09:01, 14:05, 15:01, 15:02

0.1384

  

HLA-DQB1

0

none

2.69E-12

none

3.37E-16

1

03:03

2.23E-08

04:01

1.12E-02

2

03:03, 06:02

2.62E-06

04:01, 06:02

2.16E-01

3

03:03, 06:02, 05:03

8.36E-04

  

4

03:03,06:02,05:03,06:01

0.2806

  

HLA-DPB1

0

none

2.34E-03

none

5.16E-05

1

14:01

0.0357

06:01

7.69E-03

2

14:01, 09:01

0.1787

06:01, 14:01

0.063

  1. P-value is for the 2xk chi-square test of significance of allergy status versus all HLA alleles at a locus after excluding alleles from both cases and control that were identified as “Significant alleles excluded” from the previous RPE step.
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