Table 2 SNPs with genome-wide significant associations with spontaneous PTB. OR and p-values for the other discovery and validation cohorts are given in Table S2.

From: A genome-wide association study identifies only two ancestry specific variants associated with spontaneous preterm birth

CHR

SNP

BP

Minor allele

OR

P-value

POP

Genes (distance in bp)

Case genotype counts

Control genotype counts

Validated

1

rs17591250

238386465

G

2.814

4.55E-09

AFR

RP11-136B18.1 (45329)

GG:2,GA:52

GG:3,GA:204

G,T

RP11-136B18.1 (45329)

AA:127

AA:1451

8

rs1979081

334288

A

0.566

3.72E-08

AMR

FAM87 (864)

AA:19,AG:147

AA:38,AG:352

M,I

FBXO25 (22520)

GG:535,00:35

GG:665,00:29

  1. OR - odds-ratio. POP - The population in which the association was identified. Missing genotypes are labeled as ‘00’. M, I, G, T P-value <0.05 in external cohort FIN-mothers, FIN-infants, GALA II, ITMI respectively.
Back to article page