Table 2 Genetic Risk Score (GRS) association with chronotype, food timing and metabolic syndrome components (n = 1,693).

From: Modifiable lifestyle behaviors, but not a genetic risk score, associate with metabolic syndrome in evening chronotypes

 

GRS Score

B (SE)

P

Chronotype

ME Score

−0.121 (0.058)

0.037

Metabolic syndrome and insulin resistance

MetS Score*

0.001 (0.001)

0.52

Fasting glucose (mg/dl)

−0.150 (0.160)

0.35

Triglycerides (mg/dl)*

−0.003 (0.003)

0.41

HDL-c (mg/dl)

−0.011 (0.122)

0.93

Systolic Pressure (mmHg)

0.054 (0.027)

0.043

Diastolic pressure (mmHg)

0.028 (0.017)

0.096

Waist (cm)

0.101 (0.098)

0.31

Insulin (µUI/ml)*

0.001 (0.005)

0.52

HOMA-IR*

0.001 (0.002)

0.62

  1. Adjusted by sex and age.
  2. *Values were logarithmically transformed.
  3. B represents change in outcome per each additional copy of the risk (evening) allele.
  4. Abbreviations: ME, morning-evening; MetS, Metabolic Syndrome; HDL-C, High Density Lipoprotein – Cholesterol; HOMA-IR, Homeostatic Model Assessment – Insulin Resistance.
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