Table 3 Pathway enrichment for the targets of CKI.

From: Uncovering the anticancer mechanism of Compound Kushen Injection against HCC by integrating quantitative analysis, network analysis and experimental validation

Reactome Pathway

P-value

FDR

HitGenes

Metabolism of amino acids and derivatives

0

0.002252408

AGXT, QDPR, CTH, OAT, ASS1, ARG1, FTCD, CBS

Metabolism

0.0001

0.019183984

PTGS2, AGXT, ALAS1, CD44, HPSE, QDPR, CTH, GNAS, CA2, CA1, OAT, GSTP1

FRS2-mediated cascade

0.0002

0.026828354

FGF1, FGF2, MAPK1, KRAS

FGFR1b ligand binding and activation

0.0005

0.046185577

FGF1, FGF2

Amyloids

0.0007

0.046185577

B2M, LYZ, FGA

Reversible hydration of carbon dioxide

0.0008

0.046185577

CA2, CA1

SHC-mediated cascade

0.001

0.046185577

FGF1, FGF2, KRAS

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