Table 4 The differential metabolites in SMMC-7721 cell and medium after treatment of CKI. *p < 0.05, **p < 0.01, ***p < 0.001 versus untreated cells.
No | Metabolites | CKI cell | fold change | CKI medium | fold change |
|---|---|---|---|---|---|
1 | Leucine | ↑** | 4.00 | ↓*** | 1.97 |
2 | Valine | ↑** | 5.39 | ↓*** | 1.60 |
3 | Acetate | ↑*** | 4.81 | ||
4 | Lactate | ↓*** | 5.25 | ||
5 | Pyruvate | ↑*** | 4.91 | ||
6 | Succinate | ↑*** | 2.17 | ||
7 | Pyroglutamate | ↑*** | 2.29 | ||
8 | Glutamate | ↓*** | 2.98 | ||
9 | Glutamine | ↑** | 1.52 | ||
10 | Glutathione | ↓*** | 4.10 | ||
11 | Creatine | ↓** | 2.61 | ||
12 | GPCc | ↓** | 2.57 | ||
13 | Glycine | ↓*** | 2.91 | ↑*** | 1.67 |
14 | Threonine | ↑*** | 12.76 | ||
15 | 1,3-Dihydroxyacetone | ↓** | 2.01 | ||
16 | Glycerol | ↑*** | 2.31 | ↑** | 2.08 |
17 | Alanine | ↑*** | 1.32 | ||
18 | Adenosine monophosphate | ↓* | 1.52 | ||
19 | β-Glucose | ↑** | 11.05 | ||
20 | Tyrosine | ↑*** | 3.69 | ||
21 | Phenylalanine | ↑*** | 3.34 | ||
22 | Hypoxanthine | ↓*** | 3.18 |
