Figure 4 | Scientific Reports

Figure 4

From: C-reactive protein and pentraxin-3 binding of factor H-like protein 1 differs from complement factor H: implications for retinal inflammation

Figure 4

Immunofluorescent staining of CRP and PTX3 in the macula of human donor eyes. Representative images of five (for CRP staining) and eighteen (PTX3) donor tissues are shown. (A) CRP staining in the macula region of non-AMD and AMD eyes (green) can be seen in the Bruch’s membrane (BrM) and choriocapillaris (CC), which underlie the retinal pigment epithelium (RPE); CRP staining was used as a control, given that it is known to accumulate in these locations during AMD. (B) Staining for PTX3 (green) can be seen in the stroma of the choriocapillaris (solid white arrows) and, in the case of AMD donors, cells within the blood vessels of the choroid also stain positive for PTX3 (open white arrow). (C) A higher magnification image of PTX3 staining (green) in the intercapillary septa of the choriocapillaris. In all cases blue nuclear staining is achieved with DAPI, and scale bars represent 10μm.

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