Figure 3 | Scientific Reports

Figure 3

From: RNA-seq identifies a diminished differentiation gene signature in primary monolayer keratinocytes grown from lesional and uninvolved psoriatic skin

Figure 3

Genes with decreased expression in PP-KCs and PN-KCs overlap significantly with genes near SNPs identified by psoriasis GWA studies. (A–F) Genes altered in psoriatic KCs (A–C) or whole skin (D–F) and their overlap with genes near SNPs from psoriasis GWA studies. The 500 most strongly altered genes were examined in each analysis and percent overlap with genes at varying distances from psoriasis-associated SNPs was evaluated (yellow: P < 0.05, Fisher’s Exact Test). (G–J) Genes most strongly altered in psoriasis KCs or skin (top 500) that are closest to a psoriasis-associated SNP (left margin). The estimated FC is shown for each gene (red: FDR < 0.10, FC > 2.0; blue: FDR < 0.10, FC < 0.50).

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