Figure 8
From: Connexin 43 Hemichannel as a Novel Mediator of Sterile and Infectious Inflammatory Diseases
Proposed model for the P5-mediated inhibition of HMGB1 release. Prolonged stimulation with crude LPS or SAA led to the up-regulation of Cx43, which may contribute to extracellular ATP efflux, P2X7R-mediated PKR phosphorylation, and resultant PKR-mediated pyroptosis and HMGB1 release. As a novel Cx43 inhibitor, the P5 peptide may block the LPS/SAA-induced ATP efflux, thereby impairing the PKR-mediated HMGB1 release.
