Table 2 A summary of the cumulative amount of chemical analogues, permeated through the skin after 24 hrs. Statistical comparison (one-way ANOVA, with post-hoc Tukey analysis) of the cumulative amount were compared between different chemical analogues within the same concentration of PG:H2O co-solvent system. In general, both Arg2 and Arg3 have greater permeation at 24 hrs as compared to Arg0, except in 70% PG co-solvent system where Arg0 performed significantly better than the other chemical analogues.
From: Enhanced Skin Permeation of Anti-wrinkle Peptides via Molecular Modification
Cumulative Amount Permeated Through Skin after 24 hrs | ||||
|---|---|---|---|---|
Concentration of PG (%) | Compound No. | Average (µg) | SD | P-value (Compared to Arg0) |
0 | Arg0 | 76.4 | 7.6 | 1 |
Arg1 | 61.9 | 69.0 | 0.969 | |
Arg2 | 268.5 | 8.1 | **< 0.01 | |
Arg3 | 353.6 | 38.3 | **< 0.01 | |
30 | Arg0 | 153.2 | 21.4 | 1 |
Arg1 | 61.6 | 4.5 | 0.239 | |
Arg2 | 378.2 | 67.6 | **< 0.01 | |
Arg3 | 337.0 | 81.6 | * 0.013 | |
50 | Arg0 | 53.5 | 16.6 | 1 |
Arg1 | 65.1 | 3.9 | 0.972 | |
Arg2 | 601.7 | 54.4 | **< 0.01 | |
Arg3 | 156.1 | 33.7 | * 0.022 | |
70 | Arg0 | 667.4 | 393.9 | 1 |
Arg1 | 75.5 | 4.5 | 0.026 | |
Arg2 | 350.8 | 6.9 | 0.277 | |
Arg3 | 223.5 | 35.5 | 0.095 | |
100 | Arg0 | 144.4 | 40.5 | 1 |
Arg1 | 81.6 | 29.0 | 0.218 | |
Arg2 | 649.1 | 33.8 | **< 0.01 | |
Arg3 | 454.1 | 38.4 | **< 0.01 | |
