Figure 6
Effects of sertraline, paroxetine and chlorpromazine on motility of adult S. mansoni. Adult male worms were cultured in the presence of sertraline, paroxetine, chlorpromazine or DMSO at the indicated concentrations. Motility was measured using WormAssay after 1, 5, 11 and 24 h (N = 4 replicates, 60 s recording period) and normalized to DMSO controls (set to 100%). (A,B,C) Motility (mean ± S.E.M.) plotted against time for the drug concentrations shown. (D,E,F) Motility plotted against concentration at 24 h (same data as A,B,C). The sertraline and paroxetine data could be fitted by the Hill equation whereas the chlorpromazine data could not (a linear fit is shown). Both sertraline and paroxetine had significant effects on motility at 24 h (p < 10−10; Likelihood Ratio test). (G) Shows the plots from (D) and (E) superimposed for comparison. Calculated IC50 values (the drug concentration at which motility was reduced by 50%) are shown. IC50 values for sertraline and paroxetine were not significantly different (p = 0.66; Likelihood Ratio test).
