Figure 7

Change in vessel internal diameter and visualized vessel number during infusion of vasoactive compounds. Significant differences in the change in ID from baseline were noted between SR-B1^−/−/ApoER61^h/h and SR-B1^+/−/ApoER61^h/h in response to ACh (A) and SNP (C) in relation to vessel branching order. However, ACh evoked some residual dilation in SR-B1^−/−/ApoER61^h/h mice following blockade with L-NAME+ meclofenamate relative to the baseline (G). No significant differences in visualized vessel number in relation to branching order were noted between SR-B1^−/−/ApoER61^h/h and SR-B1^+/−/ApoER61^h/h responses to ACh (B), SNP (D) and following blockade with L-NAME+ meclofenamate (F) relative to the baseline. No significant differences between groups during ACh post blockade relative to blockade alone (H). SR-B1^+/−/ApoER61^h/h, n = 8 and SR-B1^−/−/ApoER61^h/h n = 8. Values expressed as mean ± SEM. Data were analysed by 2-way ANOVA. *p < 0.05, **p < 0.01, ***p < 0.001 vs. baseline ID, ^#p < 0.05, ^p < 0.01 vs. SR-B1^+/−/ApoER61^h/h.