Figure 8
From: A novel rat CVB1-VP1 monoclonal antibody 3A6 detects a broad range of enteroviruses
Immunolabeling of CVB1 infected mouse tissue in cryo-immuno EM with 3A6 and 5D8/1. Sections from CVB1 infected (a–d) and non-infected (e,f) mouse pancreas exocrine tissue acinar cells three days post infection: labelled with antibodies 5D8/1 (panels a, b and e) and 3A6 (panels c, d and f). Infected tissues (a,c) show gross changes during infection, and panels on the right (b,d) show details of cytoplasmic membranous structures positive for CVB1 VP1. Dots indicated by arrows are protein A gold labeled antibodies. Areas of novel membranous structures formed during infection are indicated by asterisks (a,c).
