Table 1 Structural effects in liposomes destabilized by CHCl3 addition, evaluated in terms of size (DLS) and concentration (NTA) of particles.

From: Use of nanoparticle concentration as a tool to understand the structural properties of colloids

CHCl3 (molecules/mL)

Size (nm)

Liposome concentration (particles/mL)

DPPC per liposome (molecules/particle)

0

116.5 ± 1.8

9.4 ± 0.7 × 1011

8.0 × 104

7.2 × 1016

171.8 ± 2.3

6.4 ± 0.2 × 1011

11.7 × 104

11.4 × 1016

491.9 ± 19.4

3.1 ± 0.6 × 1011

24.2 × 104

15.0 × 1016

657.6 ± 17.0

2.1 ± 0.1 × 1011

35.7 × 104

  1. The number of DPPC molecules per vesicle was calculated from the number of particles and DPPC concentration (mol/L) in the formulation.
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