Figure 7 | Scientific Reports

Figure 7

From: Uncoupled mitochondria quickly shorten along their long axis to form indented spheroids, instead of rings, in a fission-independent manner

Figure 7

Three-dimensional interactions between the mitochondrial lumen and endoplasmic reticulum (ER) through the orifice in CCCP-treated vase-shaped mitochondria. In serial cross-sections by FIB-SEM (a), the endoplasmic reticulum occasionally appeared in the lumen of vase-shaped mitochondria induced by CCCP, and the ER frequently contacted the outer membrane of mitochondrial invaginations (arrows). The 3D reconstruction showed that the ER rose from the cytosol, entered the lumen of the mitochondria through the orifice, and spread into the lumen (b). Similar mitochondria with ER-associated lumina were observed in 14.6% of vase-shaped mitochondria. Scale bar, 1 μm.

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