Table 2 Comparisons of laboratory characteristics between fatal and nonfatal patients from three to twenty days post the onset of severe fever with thrombocytopenia syndrome.

From: The Regulation of Seventeen Inflammatory Mediators are Associated with Patient Outcomes in Severe Fever with Thrombocytopenia Syndrome

Index*

3–7 days

8–12 days

13–20 days

Fatal patients (N = 11)

Nonfatal patients (N = 22)

Fatal patients (N = 9)

Nonfatal patients (N = 22)

Fatal patients (N = 5)

Nonfatal patients (N = 20)

Viral load (log10)

7 (6–8)a

4(4–5)

6 (5.7–7.7)a

3 (2–3)

5 (4.7–7.7)a

2 (2–3)

PLT count (x109/L)

33 (25–33)b

51(43.5–66)

29 (19–59)b

55 (36–68)

41 (23.5–61)a

156.5 (84–193)

WBC count (x109/L)

2 (1.5–5.5)

2.1(1.76–3.9)

4.4 (3.5–12.3)

3.7 (2.6–6)

11.4 (6.2–16.6)b

4.6 (3.4–6.8)

EOS count (x109/L)

0 (0–0.01)

0 (0–0.1)

0 (0–0.005)

0 (0–0.02)

0.01 (0.005–0.06)

0.02 (0.01–0.06)

HEM (%)

30.1 ± 6.4b

36.5 ± 4.7

33.4 ± 5.4

36.1 ± 4.4

27.6 ± 11.2

33.6 ± 5

LDH (U/L)

1879 (1078–2315)

1075 (633–1850)

1775 (1324–2770)b

879 (645–1563)

1311 (812–2517)b

335 (290–503)

CK (U/L)

648 (276–1592)b

309 (112–478)

1494 (401–3373)b

238.5 (155–649)

1283 (569–2170)a

68 (43–112.5)

CKMB (U/L)

54 (31–87)

17.5 (10.5–23.5)

63 (53–83.5)b

18.5 (13.8–28)

84 (28.5–110.5)a

11 (7–14.8)

ALT (U/L)

111 (73–190)

82.5 (48–189)

140 (70–259.5)

84 (51.5–165.5)

72 (42–118.5)

73.5 (52.3–119)

AST (U/L)

349 (100–572)

143.5 (103–512)

374 (89.5–647)

193 (83.3–482.8)

190 (95.5–424.5)b

68 (45.8–96)

BUN (mmol/L)

7 (6.3–10.7)b

5.8 (4.2–6.6)

7.5 (4.2–12.9)

4.7 (3.7–6.6)

13.9 (8.6–34.8)a

4.4 (3–5.2)

Cr (mmol/L)

97 (88–133)b

74.5 (60.3–88)

97 (53.4–148.5)

72.5 (60.5–83.3)

103 (74.5–118.5)b

50.5 (43.5–71)

Amylase (U/L)

158 (79–269)

135 (82.8–359)

229 (152–299)

137 (85–386)

357 (180–608.5)

125.5 (65–253)

Lipase (U/L)

608 (101–1169)

407 (129–1151)

512 (256–1277)

436.5 (118–861)

902 (306–2169)b

168.5 (73–572)

Na (mmol/L)

127.9 ± 4.9b

133.9 ± 4.8

127.7 ± 5.1b

133.9 ± 4.8

129.6 ± 4.1

135.1 ± 5.1

Proteinuria, N (%)

100

86.4

100

81.8

100b

30

Hematuria, N (%)

90.9

63.6

88.9

50

80b

5

  1. *Data of HEM and Na are presented as mean ± standard deviation, data of Proteinuria and Hematuria are presented as proportion, other data are presented as median (interquartile range).
  2. a p < 0.001, b p < 0.05 compared with nonfatal patients.
  3. Abbreviations: PLT, platelet; WBC, white blood cell; EOS, eosinophil; HEM, hematocrit; LDH, lactate dehydrogenase; CK, creatine kinase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; BUN, blood urea nitrogen; Cr, creatinine; U/L, units/liter.