Figure 10 | Scientific Reports

Figure 10

From: Flavin Reductase Contributes to Pneumococcal Virulence by Protecting from Oxidative Stress and Mediating Adhesion and Elicits Protection Against Pneumococcal Challenge

Figure 10

Vaccine potential of rFlaR. Immunization of BALB/c mice with rFlaR conferred significant protection against IP lethal S. pneumoniae challenge. (a) 15 µg (Log-rank (Mantel-Cox) test, n = 7 in the control and n = 17 in the immunized group, *p = 0.0388) and (b) 25 µg rFlaR in the presence of alum as an adjuvant and (Log-rank (Mantel-Cox) test, n = 7 in the control and n = 17 in the immunized group,***p = 0.0001) (c). 35 µg rFlaR using CFA in primary immunization and IFA in booster immunizations (Log-rank (Mantel-Cox) test, n = 19 in the control and n = 14 in the immunized group,**p = 0.0053). (d) BALB/c mice inoculated IP with WU2 WT treated with anti-rFlaR antiserum obtained from immunized rabbits survived significantly longer then mice inoculated with WU2 WT treated ex-vivo with preimmune serum (Log-rank (Mantel-Cox) test, n = 10 in the control and n = 10 in the immunized group, ****p < 0.0001).

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